MOB1A Antibody, Biotin conjugated - Cat. #: CSB-PA872519HD01HU

SKU: CSB-PA872519HD01HU

Size :50ug

Clone Number:

Aliases:B1; Mps One Binder kinase activator like 1B (yeast) antibody; C2orf6 antibody; Chromosome 2 open reading frame 6 antibody; FLJ10788 antibody; FLJ11595 antibody; MATS1 antibody; MOB kinase activator 1A antibody; MOB1 antibody; Mob1 alpha antibody; Mob1 homolog 1B antibody; MOB1 Mps One Binder homolog A antibody; MOB1 Mps One Binder kinase activator like 1B antibody; Mob1A antibody; MOB4B antibody; Mob4B protein antibody; MOBK1B antibody; Mobkl1b antibody; MOL1B_HUMAN antibody; Mps one binder kinase activator like 1B antibody; Mps one binder kinase activator-like 1B antibody; Protein Mob4B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H8S9

Immunogen:Recombinant Human MOB kinase activator 1A protein (2-216AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MOB1A

Research Areas:Cancer; Signal transduction