MMS19 antibody , Cat. # FNab05249

SKU: FNab05249

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:6H1

Isotype:IgG2a

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Immunogen:MMS19 nucleotide excision repair homolog(S. cerevisiae)

Synonyms:MMS19L

Observed MW:103 kDa

Uniprot ID:Q96T76

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IF, IHC

Recommended dilution:WB: 1:1000-1:4000; IHC: 1:20-1:200; IF: 1:20-1:200

Gene ID:64210

Research Area:Metabolism