MMP25 Polyclonal Antibody

SKU: E-AB-12571

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:MMP25

Target Synonym:Leukolysin;matrix metallopeptidase 25;matrix metallopeptidase like 1;matrix metalloproteinase 20;Matrix Metalloproteinase 25;Matrix metalloproteinase 25 precursor;Matrix metalloproteinase-25;Membrane type 6 Matrix Metalloproteinase;Membrane type Matrix Metalloproteinase 6;Membrane-type matrix metalloproteinase 6;Membrane-type-6 matrix metalloproteinase;MMP 25;MMP-25;MMP20;MMP20A;MMP25;MMP25;MMPL1;MT-MMP 6;MT6-MMP;MT6MMP;MTMMP6

Research Areas:Cancer;Cell Biology;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q9NPA2

Accession:

Background:Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.

Concentration:0.5 mg/mL

Immunogen:Synthetic peptide of human MMP25

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW: