MICAL2 Antibody - Cat. #: CSB-PA013808LA01HU

SKU: CSB-PA013808LA01HU

Size :50ug

Clone Number:

Aliases:MICAL2 antibody; KIAA0750 antibody; MICAL2PV1 antibody; MICAL2PV2 antibody; [F-actin]-monooxygenase MICAL2 antibody; EC 1.14.13.225 antibody; Molecule interacting with CasL protein 2 antibody; MICAL-2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O94851

Immunogen:Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MICAL2

Research Areas:Cell biology