MIA3 antibody , Cat. # FNab05174

SKU: FNab05174

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII(COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum(PubMed:27138255).

Immunogen:melanoma inhibitory activity family, member 3

Synonyms:KIAA0268, TANGO, TANGO1

Observed MW:250 kDa

Uniprot ID:Q5JRA6

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IP, WB

Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000

Gene ID:375056

Research Area:Signal Transduction