METTL1 Monoclonal Antibody

SKU: AN200120P

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:METTL1

Target Synonym:METTL;C12orf;C12orf1;METTL1;D1075 like gene product;FLJ95748;Methyltransferase like 1;Methyltransferase like protein 1;Methyltransferase-like protein 1;TRM8;TRMB_HUMAN;TRMT8;tRNA (guanine N(7) ) methyltransferase;tRNA (guanine(46)-N(7))-methyltransferase;tRNA (guanine-N(7)-)-methyltransferase;tRNA(m7G46) methyltransferase;tRNA(m7G46)-methyltransferase;YDL201w

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB;IP

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:4F5

UNIProt ID:Q9UBP6

Accession:

Background:tRNA (guanine-N(7)-)-methyltransferase, also known as Methyltransferase-like protein 1, tRNA (m7G46)-methyltransferase and METTL1, is a nucleus protein that belongs to the methyltransferase superfamily and TrmB family. METTL1 gene has been identified by its sequence similarity to the yeast ORF YDL21w. The human cDNA and the genomic structure of METTL1 have been analyzed. The transcript contains 1292 nucleotides and codes for a protein of 276 amino acids. The METTL1 gene product shows high sequence similarities to putative proteins from mouse, Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, and yeast (39.8% identity between all six species). Computer analyses of the deduced protein sequence reveal two highly conserved amino acid motifs, one of which is typical for methyltransferases. Both motifs are also present in hypothetical proteins from eubacteria. Disruption of the homologous yeast ORF YDL21w shows that the gene is at least not essential for vegetative growth in Saccharomyces cerevisiae.

Concentration:1 mg/mL

Immunogen:Recombinant Human METTL1 protein

Buffer:0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0

Purification method:Protein A

Dilution:WB 1:500-1:2000;IP 4-6 μL/mg of lysate

Calculated MW:34 kDa

ObservedMW:34 kDa