MEN1 Antibody - Cat. #: CSB-PA013694HA01HU

SKU: CSB-PA013694HA01HU

Size :50ug

Clone Number:

Aliases:MEA 1 antibody; MEA1 antibody; MEN 1 antibody; Men1 antibody; MEN1_HUMAN antibody; Menin antibody; Multiple Endocrine Adenomatosis 1 antibody; Multiple Endocrine Neoplasia 1 antibody; SCG 2 antibody; SCG2 antibody; Suppressor Candidate Gene 2 antibody; Wermer syndrome antibody; ZES antibody; Zollinger Ellison Syndrome antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O00255

Immunogen:Recombinant Human Menin protein (1-615AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates \\\'Lys-4\\\' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MEN1

Research Areas:Epigenetics and Nuclear Signaling; Cancer