MEF2C Antibody - Cat. #: CSB-PA804958ESR1HU

SKU: CSB-PA804958ESR1HU

Size :50ul

Clone Number:

Aliases:C5DELq14.3 antibody; DEL5q14.3 antibody; MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody; MADS box transcription enhancer factor 2, polypeptide C antibody; MEF2C antibody; MEF2C_HUMAN antibody; Myocyte enhancer factor 2C antibody; Myocyte specific enhancer factor 2C antibody; Myocyte-specific enhancer factor 2C antibody; OTTHUMP00000222409 antibody; Similar to MADS box transcription enhancer factor 2 polypeptide C antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q06413

Immunogen:Recombinant Human Myocyte-specific enhancer factor 2C protein (170-380AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Background:Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MEF2C

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cardiovascular; Signal transduction; Stem cells