MED12 Antibody - Cat. #: CSB-PA259630

SKU: CSB-PA259630

Size :50ul

Clone Number:

Aliases:Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; ARC240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody; MED12 antibody; MED12_HUMAN antibody; Mediator complex subunit 12 antibody; Mediator of RNA polymerase II transcription subunit 12 antibody; OPA containing protein antibody; OPA-containing protein antibody; Thyroid hormone receptor associated protein complex 230 kDa component antibody; Thyroid hormone receptor-associated protein complex 230 kDa component antibody; TNRC11 antibody; Trap230 antibody; Trinucleotide repeat containing gene 11 protein antibody; Trinucleotide repeat-containing gene 11 protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q93074

Immunogen:Synthetic peptide of Human MED12

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100

Background:The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MED12

Research Areas:Epigenetics and Nuclear Signaling