MC1R Antibody - Cat. #: CSB-PA122172

SKU: CSB-PA122172

Size :50ul

Clone Number:

Aliases:CMM5 antibody; MC1 Receptor antibody; MC1-R antibody; MC1R antibody; Melanocortin 1 receptor antibody; Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody; Melanocortin receptor 1 antibody; Melanocyte-stimulating hormone receptor antibody; Melanotropin receptor antibody; MSH-R antibody; MSHR antibody; MSHR_HUMAN antibody; SHEP2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q01726

Immunogen:Synthetic peptide of Human MC1R

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:50-1:200

Background:This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MC1R

Research Areas:Neuroscience;Metabolism