MBTPS1 Antibody - Cat. #: CSB-PA237035

SKU: CSB-PA237035

Size :100ul

Clone Number:

Aliases:MBTPS1 antibody; KIAA0091 antibody; S1P antibody; SKI1Membrane-bound transcription factor site-1 protease antibody; EC 3.4.21.112 antibody; Endopeptidase S1P antibody; Subtilisin/kexin-isozyme 1 antibody; SKI-1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q14703

Immunogen:Synthesized peptide derived from C-terminal of Human MBTPS1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Nakajima T., J. Hum. Genet. 45:212-217(2000).
Nagase T., DNA Res. 2:37-43(1995).
Bechtel S., BMC Genomics 8:399-399(2007).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MBTPS1

Research Areas:Epigenetics and Nuclear Signaling;Cell biology;Metabolism;Signal transduction