MBP Antibody - Cat. #: CSB-PA261629

SKU: CSB-PA261629

Size :100ul

Clone Number:

Aliases:GDB antibody; Golli MBP antibody; Golli MBP; myelin basic protein antibody; Hemopoietic MBP antibody; HMBPR antibody; HUGO antibody; MBP antibody; MBP_CAVPO antibody; MBP_HUMAN antibody; MGC99675 antibody; MLD antibody; Myelin A1 protein antibody; Myelin A1 Protein; basic antibody; Myelin basic protein antibody; Myelin Deficient antibody; Myelin membrane encephalitogenic protein antibody; OTTHUMP00000163776 antibody; OTTHUMP00000174387 antibody; OTTHUMP00000174388 antibody; SHI antibody; Shiverer antibody; SP antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P02686

Immunogen:Peptide sequence around aa.291~295(G-G-R-D-S

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Pribyl T.M., Campagnoni C.W., Kampf K. Proc. Natl. Acad. Sci. U.S.A. 90:10695-10699(1993)
Nye S.H., Pelfrey C.M., Burkwit J.J. Mol. Immunol. 32:1131-1141(1995)

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MBP

Research Areas:Neuroscience;Tags & Cell Markers