MAPK7 Antibody - Cat. #: CSB-PA013465ESR1HU

SKU: CSB-PA013465ESR1HU

Size :50ul

Clone Number:

Aliases:Big MAP kinase 1 antibody; BMK 1 antibody; BMK 1 kinase antibody; BMK-1 antibody; BMK1 antibody; BMK1 Kinase antibody; EC 2.7.11.24 antibody; ERK 4 antibody; ERK 5 antibody; ERK-5 antibody; ERK4 antibody; ERK5 antibody; Extracellular signal regulated kinase 5 antibody; Extracellular signal-regulated kinase 5 antibody; MAP kinase 7 antibody; MAPK 7 antibody; MAPK7 antibody; Mitogen activated protein kinase 7 antibody; Mitogen-activated protein kinase 7 antibody; MK07_HUMAN antibody; OTTHUMP00000065906 antibody; OTTHUMP00000065907 antibody; PRKM 7 antibody; PRKM7 antibody; PROTEIN KINASE; MITOGEN-ACTIVATED; 7 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13164

Immunogen:Recombinant Human Mitogen-activated protein kinase 7 protein (1-310AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MAPK7

Research Areas:Neuroscience; Signal transduction