MAPK10 Monoclonal Antibody

SKU: BT-MCA2495

Size:100μL

Background:MAPK10: mitogen-activated protein kinase 10, also known as JNK3, JNK3A, PRKM10, p54bSAPK. Entrez Protein NP_002744. It is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Research_area:Neuroscience

Target_protein:MAPK10

applications:WB, ICC

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:10E4A4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MAPK10

Immunogen:Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):53kDa

UniProt accession:P53779

Synonyms:JNK3, JNK3A, PRKM10, p54bSAPK

GeneID:5602