MAF Antibody - Cat. #: CSB-PA796747

SKU: CSB-PA796747

Size :100ul

Clone Number:

Aliases:AS42 oncogene homolog antibody; Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene antibody; Avian musculoaponeurotic fibrosarcoma (v maf) antibody; c maf proto oncogene antibody; cMaf antibody; maf antibody; MAF_HUMAN antibody; MAF2 antibody; MGC71685 antibody; Proto oncogene c Maf antibody; Proto-oncogene c-maf antibody; Transcription factor Maf antibody; v maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) antibody; v maf musculoaponeurotic fibrosarcoma oncogene homolog antibody; V-maf musculoaponeurotic fibrosarcoma oncogene homolog antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75444

Immunogen:Synthesized peptide derived from Internal of Human Maf.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells By similarity. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.

Chesi M., Blood 91:4457-4463(1998).
Jamieson R.V., Hum. Mol. Genet. 11:33-42(2002).
Vanita V., Am. J. Med. Genet. A 140:558-566(2006).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MAF

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Immunology