Lcn2 Antibody, Biotin conjugated - Cat. #: CSB-PA012816LD01RA

SKU: CSB-PA012816LD01RA

Size :50ul

Clone Number:

Aliases:Lcn2 antibody; Neutrophil gelatinase-associated lipocalin antibody; NGAL antibody; Alpha-2-microglobulin-related protein antibody; Alpha-2U globulin-related protein antibody; Lipocalin 24p3 antibody; Lipocalin-2 antibody; Siderocalin LCN2 antibody; p25 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Rattus norvegicus (Rat)

UniProt ID:P30152

Immunogen:Recombinant Rat Lcn2 protein (1-198AA)

Raised in:Rabbit

Species Reactivity:Rat

Tested Applications:ELISA

Background:Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (By similarity). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:Lcn2

Research Areas:Cardiovascular