L2 Antibody, FITC conjugated - Cat. #: CSB-PA365848LC01HML

SKU: CSB-PA365848LC01HML

Size :50ug

Clone Number:

Aliases:L2 antibody; Minor capsid protein L2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human) papillomavirus type 16

UniProt ID:P03107

Immunogen:Recombinant Human papillomavirus type 16 Minor capsid protein L2 protein (1-473AA)

Raised in:Rabbit

Species Reactivity:Human papillomavirus type 16

Tested Applications:

Background:Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:L2

Research Areas:Others