KRT17 Antibody, Biotin conjugated - Cat. #: CSB-PA012516LD01BO

SKU: CSB-PA012516LD01BO

Size :50ug

Clone Number:

Aliases:KRT17 antibody; Keratin antibody; type I cytoskeletal 17 antibody; Cytokeratin-17 antibody; CK-17 antibody; Keratin-17 antibody; K17 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Bos taurus (Bovine)

UniProt ID:A1L595

Immunogen:Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA)

Raised in:Rabbit

Species Reactivity:Bovine

Tested Applications:ELISA

Background:Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial \"stem cells\". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KRT17

Research Areas:Others