KNG1 Antibody, Biotin conjugated - Cat. #: CSB-PA14647D0Rb

SKU: CSB-PA14647D0Rb

Size :50ug

Clone Number:

Aliases:Alpha-2-thiol proteinase inhibitor antibody; BDK antibody; BK antibody; Bradykinin antibody; Bradykinin included antibody; Fitzgerald factor antibody; FLAUJEAC FACTOR antibody; High molecular weight kininogen antibody; HMWK antibody; Ile-Ser-Bradykinin antibody; Kallidin I antibody; Kallidin II antibody; KNG antibody; KNG1 antibody; KNG1_HUMAN antibody; Low molecular weight growth-promoting factor antibody; WILLIAMS FACTOR antibody; Williams-Fitzgerald-Flaujeac factor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P01042

Immunogen:Recombinant Human Kininogen-1 protein (390-644AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KNG1

Research Areas:Cardiovascular; Signal transduction