KLOTB Polyclonal Antibody

SKU: BT-AP10733

Size:100μL

Background:Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive.,Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.,Belongs to the glycosyl hydrolase 1 family.,Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.,subunit:Interacts with FGFR1 and FGFR4.,

Research_area:Metabolism; Signal transduction; Cardiovascular; Epigenetics and nuclear signaling

Target_protein:KLB

applications:WB, ELISA

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Beta-klotho

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q86Z14; Mouse: Q99N32

Synonyms:Beta-klotho ;BKL;BetaKlotho;Klotho beta-like protein

GeneID:Human: 152831