KITLG Antibody - Cat. #: CSB-PA012376ESR2HU

SKU: CSB-PA012376ESR2HU

Size :50ul

Clone Number:

Aliases:C kit ligand antibody; C-kit ligand antibody; Ckit ligand antibody; DCUA antibody; DFNA69 antibody; DKFZp686F2250 antibody; familial progressive hyperpigmentation 2 antibody; FPH2 antibody; FPHH antibody; KIT ligand antibody; Kitl antibody; KITLG antibody; KL 1 antibody; KL1 antibody; Mast cell growth factor antibody; MGF antibody; MGF stem cell factor antibody; SCF antibody; SCF_HUMAN antibody; SF antibody; SHEP7 antibody; sKITLG antibody; Soluble KIT ligand antibody; Steel factor antibody; steel, mouse, homolog of antibody; Stem cell factor antibody; Stem cell factor precursor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P21583

Immunogen:Recombinant Human Kit ligand protein (26-214AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000

Background:Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KITLG

Research Areas:Developmental biology; Immunology; Stem cells