KCNJ11 Polyclonal Antibody

SKU: E-AB-11188

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:KCNJ11

Target Synonym:ATP sensitive inward rectifier potassium channel 11;Beta cell inward rectifier subunit;BIR;HHF 2;HHF2;IKATP;Inward rectifier K(+) channel Kir6.2;Inwardly rectifying potassium channel KIR6.2;IRK 11;IRK11;KCNJ11;Kir 6.2;Kir6.2;MGC133230;PHHI;Potassium channel inwardly rectifing subfamily J member 11;Potassium channel;inwardly rectifying subfamily J member 11;Potassium inwardly rectifying channel J11;TNDM 3;TNDM3

Research Areas:Cancer;Cardiovascular;Metabolism;Neuroscience;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q14654

Accession:

Background:Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Concentration:0.6 mg/mL

Immunogen:Recombinant protein of human KCNJ11

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW: