JMJD6 Antibody - Cat. #: CSB-PA750768ESR1HU

SKU: CSB-PA750768ESR1HU

Size :50ul

Clone Number:

Aliases:Apoptotic cell clearance receptor antibody; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody; Histone arginine demethylase JMJD6 antibody; JmjC domain-containing protein 6 antibody; JMJD 6 antibody; JMJD6 antibody; JMJD6_HUMAN antibody; Jumonji domain containing 6 antibody; Jumonji domain-containing protein 6 antibody; KIAA0585 antibody; Lysyl-hydroxylase JMJD6 antibody; Peptide-lysine 5-dioxygenase JMJD6 antibody; Phosphatidylserine receptor antibody; Protein PTDSR antibody; PSR antibody; PTDSR 1 antibody; PTDSR antibody; PTDSR1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q6NYC1

Immunogen:Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 protein (1-320AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at \\\'Arg-2\\\' (H3R2me) and histone H4 at \\\'Arg-3\\\' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:JMJD6

Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Developmental biology; Immunology; Stem cells