IWS1 Antibody - Cat. #: CSB-PA822304ESR2HU

SKU: CSB-PA822304ESR2HU

Size :50ul

Clone Number:

Aliases:DKFZp761G0123 antibody; FLJ10006 antibody; FLJ14655 antibody; FLJ32319 antibody; Interacts with Spt6 antibody; iws1 antibody; IWS1 homolog antibody; IWS1-like protein antibody; IWS1_HUMAN antibody; IWS1L antibody; MGC126375 antibody; MGC126376 antibody; OTTHUMP00000162262 antibody; Protein IWS1 homolog antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96ST2

Immunogen:Recombinant Human Protein IWS1 homolog protein (570-819AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IWS1

Research Areas:Epigenetics and Nuclear Signaling