IPO13 Antibody - Cat. #: CSB-PA011776LA01HU

SKU: CSB-PA011776LA01HU

Size :50ug

Clone Number:

Aliases:Imp 13 antibody; Imp13 antibody; Importin-13 antibody; Importin13 antibody; IPO 13 antibody; Ipo13 antibody; IPO13_HUMAN antibody; Kap 13 antibody; Kap13 antibody; Karyopherin 13 antibody; Karyopherin-13 antibody; Karyopherin13 antibody; KIAA0274 antibody; Late gestation lung 2 antibody; Late gestation lung 2 protein antibody; Lgl2 antibody; Ran binding protein 13 antibody; Ran-binding protein 13 antibody; RanBP 13 antibody; RanBP13 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O94829

Immunogen:Recombinant Human Importin-13 protein (501-700AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IPO13

Research Areas:Others