ING4 antibody , Cat. # FNab04313

SKU: FNab04313

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's(HIF) activity by interacting with HIF prolyl hydroxylase 2(EGLN1). Can enhance aopotosis induced by serum starvation in mammary epithelial cell line HC11(By similarity).

Immunogen:inhibitor of growth family, member 4

Synonyms:ING4, Inhibitor of growth protein 4, my036, P29ing4

Observed MW:29kd

Uniprot ID:Q9UNL4

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IF, IP

Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200; IP: 1:200-1:2000

Gene ID:51147

Research Area:Cancer, Metabolism