IMPACT Antibody - Cat. #: CSB-PA889191LA01HU

SKU: CSB-PA889191LA01HU

Size :50ug

Clone Number:

Aliases:IMPACT antibody; Impact homolog (mouse) antibody; Impact homolog antibody; impact RWD domain protein antibody; IMPCT_HUMAN antibody; Imprinted and ancient gene protein homolog antibody; MGC33718 antibody; Protein IMPACT antibody; RWD domain containing 5 antibody; RWDD5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9P2X3

Immunogen:Recombinant Human Protein IMPACT protein (41-320AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its action on GCN2, may also facilitate neuritogenesis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IMPACT

Research Areas:Epigenetics and Nuclear Signaling