IL18 Polyclonal Antibody

SKU: E-AB-93262

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:IL18

Target Synonym:Ig; Il-; Igif; Il-18

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P70380

Accession:

Background:Interleukin-18 (L-18) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.

Concentration:1mg/mL

Immunogen:Recombinant fusion protein of mouse IL18

Buffer:PBS with 0.05% proclin300,50% glycerol,pH7.3.

Purification method:Affinity purification

Dilution:WB 1:500-1:2000;IHC 1:50-1:200

Calculated MW:22kDa

ObservedMW:22kDa/18kDa