IKZF1 Antibody, HRP conjugated - Cat. #: CSB-PA621668LB01HU

SKU: CSB-PA621668LB01HU

Size :50ug

Clone Number:

Aliases:CLL associated antigen KW 6 antibody; DNA-binding protein Ikaros antibody; hIk 1 antibody; Hs.54452 antibody; IK1 antibody; Ikaros (zinc finger protein) antibody; IKAROS antibody; IKAROS family zinc finger 1 (Ikaros) antibody; Ikaros family zinc finger protein 1 antibody; Ikzf1 antibody; IKZF1_HUMAN antibody; LYF1 antibody; Lymphoid transcription factor LyF-1 antibody; PRO0758 antibody; Zinc finger protein subfamily 1A 1 (Ikaros) antibody; Zinc finger protein subfamily 1A 1 antibody; Zinc finger protein; subfamily 1A; member 1 antibody; ZNFN1A1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13422

Immunogen:Recombinant Human DNA-binding protein Ikaros protein (1-265AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IKZF1

Research Areas:Epigenetics and Nuclear Signaling; Cancer