IGF2BP3 Monoclonal Antibody

SKU: BT-MCA2829

Size:100μL

Background:The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism.Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines .IMP-3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.

Research_area:Epigenetics and nuclear signaling, Cancer

Target_protein:IGF2BP3

applications:WB, IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:8F11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:IGF2BP3

Immunogen:Purified recombinant fragment of human IGF2BP3 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):69kDa

UniProt accession:O00425

Synonyms:CT98, IMP3, KOC1, IMP-3, VICKZ3, DKFZp686F1078, IGF2BP3

GeneID:10643