IGF1R Monoclonal Antibody

SKU: BT-MCA4754

Size:100μL

Background:This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Research_area:Others

Target_protein:IGF1R

applications:WB, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:3B4E3

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:IGF1R

Immunogen:Purified recombinant fragment of human IGF1R (AA: extra(741-935)) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):154.8kDa

UniProt accession:P08069

Synonyms:IGFR, CD221, IGFIR, JTK13

GeneID:3480