IGF-I Receptor β (phospho-Tyr980) rabbit pAb

SKU: ES15513

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Mouse;Rat

Dilution:WB 1:1000-2000

Immunogen:Synthesized phosho peptide around human IGF-I Receptor β (Tyr980)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):pro: 155kD, recetor beta: 95kD

Human_gene_id:3480

Human_swiss_prot_no:P08069

Subcellular_location:Cell membrane ; Single-pass type I membrane protein .

Other_name:Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

Background:This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],