Human Tyrosine-protein Kinase Hck, HCK ELISA Kit

SKU: E6360Hu

Size:96 Tests-1 Kit

Background:Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

Research_area:Others

Applications:ELISA

Target_protein:HCK

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.59ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine-protein kinase HCK

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08631

MASS(Da):59,600

GeneID:3055

Synonyms:HCK;Hematopoietic cell kinase;Hemopoietic cell kinase;JTK9;p59Hck;p59-HCK/p60-HCK;p61Hck;Tyrosine-protein kinase HCK

Gene names:HCK

Standard solution:2400ng/L