Human Tyrosine-protein Kinase Csk, CSK ELISA Kit

SKU: E6359Hu

Size:96 Tests-1 Kit

Background:Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:CSK

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.58ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine-protein kinase CSK

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P41240

MASS(Da):50,704

GeneID:1445

Synonyms:CSK;C-Src kinase;Protein-tyrosine kinase CYL;Tyrosine-protein kinase CSK

Gene names:CSK

Standard solution:2400ng/L