Human tRNA pseudouridine synthase Pus10,PUS10 ELISA KIT

SKU: E2473Hu

Size:96 Tests-1 Kit

Background:Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588). {ECO:0000269|PubMed:14527409, ECO:0000269|PubMed:19712588, ECO:0000269|PubMed:30530625, ECO:0000269|PubMed:31819270}.

Research_area:

Applications:ELISA

Target_protein:PUS10

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.42ng/ml

Detection range:3.13-200ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Pseudouridylate Synthase 10

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q3MIT2

MASS(Da):60244

GeneID:150962

Synonyms:PUS10 CCDC139 DOBI

Gene names:PUS10

Standard solution:400ng/ml