Human Transient Receptor Potential Cation Channel Subfamily V Member 4, TRPV4 ELISA Kit

SKU: E6305Hu

Size:96 Tests-1 Kit

Background:Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca2+ in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. Lacks channel activity, due to impaired oligomerization and intracellular retention. Lacks channel activity, due to impaired oligomerization and intracellular retention. Lacks channel activity, due to impaired oligomerization and intracellular retention. (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X.

Research_area:Others

Applications:ELISA

Target_protein:TrpV4

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.99ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transient receptor potential cation Channel subfamily V member 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9HBA0

MASS(Da):98,281

GeneID:59341

Synonyms:BCYM3;CMT2C;HMSN2C;Osm-9-like TRP Channel 4;OTRPC4;SMAL;SPSMA;SSQTL1;Transient receptor potential cation Channel subfamily V member 4;Transient receptor potential protein 12;TRP12;TrpV4;Vanilloid receptor-like Channel 2;Vanilloid receptor-like protein 2;Vanilloid receptor-related osmotically-activated Channel;VRL2;VRL-2;VR-OAC

Gene names:TRPV4

Standard solution:2400ng/L