Human TPP1/Tripeptidyl-peptidase 1 ELISA Kit PicoKine®

SKU: EK2042

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TPP1

Specificity: Natural and recombinant human TPP1

Background: Tripeptidyl-peptidase 1, also known as Lysosomal pepstatin-insensitive protease, is an enzyme that in humans is encoded by the TPP1 gene. The human gene TPP1 encodes a member of the sedolisin family of serine proteases. The human gene has 13 exons and locates at the chromosome band 11p15. This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L196-P563

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Reference:

Uniprot ID: O14773

Host:

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1200

Protein Name: Tripeptidyl-peptidase 1

Gene Full Name: tripeptidyl peptidase 1

Synonyms: CLN2; GIG1; LPIC; TPP 1; TPP I; TPP1; Tripeptidyl aminopeptidase; Tripeptidyl peptidase 1; tripeptidyl peptidase I; UNQ267/PRO304