Human Toll-like Receptor 1, TLR1 ELISA Kit

SKU: E0363Hu

Size:96 Tests-1 Kit

Background:Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed: 21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed: 16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Research_area:Immunology

Applications:ELISA

Target_protein:TLR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.09ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Toll-Like Receptor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q15399

MASS(Da):90,291

GeneID:7096

Synonyms:CD antigen CD281;TIL;TLR 1;TLR1;Toll/interleukin-1 receptor-like protein;Toll-like receptor 1

Gene names:TLR1

Standard solution:80ng/ml