Human TNFSF13/APRIL ELISA Kit PicoKine®

SKU: EK0921

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFSF13

Specificity: Natural and recombinant human TNFSF13

Background: Tumor necrosis factor ligand superfamily member 13 (TNFSF13) also known as a proliferation-inducing ligand (APRIL) is a protein that in humans is encoded by the TNFSF13 gene. TNFSF13 has also been designated CD256 (cluster of differentiation 256). The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in April showed a reduced ability to support plasma cell survival In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such asTNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The TNFSF13 gene lies 878 bp downstream of the TNFSF12 gene on chromosome 17p13.1.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A105-L250

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Uniprot ID: O75888

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 8741

Protein Name: Tumor necrosis factor ligand superfamily member 13

Gene Full Name: TNF superfamily member 13

Synonyms: APRIL; CD256; ligand; TALL 2; TALL2; TNF related death ligand 1; TNFSF13; TRDL 1; UNQ383/PRO715; ZTNF2