Human Tnf Receptor Associated Factor 6, TRAF6 ELISA Kit

SKU: E2607Hu

Size:96 Tests-1 Kit

Background:E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:TRAF6

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.57ng/L

Detection range:20-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tnf Receptor Associated Factor 6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y4K3

MASS(Da):59,573

GeneID:7189

Synonyms:E3 ubiquitin-protein ligase TRAF6;Interleukin-1 signal transducer;RING finger protein 85;RING-type E3 ubiquitin transferase TRAF6;TNF receptor-associated factor 6;TRAF 6;TRAF6

Gene names:TRAF6

Standard solution:4000ng/L