Human Thioredoxin-interacting Protein, TXNIP ELISA Kit

SKU: E6269Hu

Size:96 Tests-1 Kit

Background:May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Research_area:Cell Biology

Applications:ELISA

Target_protein:TXNIP

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.17ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Thioredoxin-Interacting Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9H3M7

MASS(Da):43,661

GeneID:10628

Synonyms:Thioredoxin-binding protein 2;Thioredoxin-interacting protein;TXNIP;Vitamin D3 up-regulated protein 1

Gene names:TXNIP

Standard solution:2400ng/L