Human Suppressors of Cytokine Signaling 1, SOCS1 ELISA Kit

SKU: E2960Hu

Size:96 Tests-1 Kit

Background:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Research_area:Others

Applications:ELISA

Target_protein:SOCS1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.102ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Suppressors of Cytokine Signaling 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15524

MASS(Da):23,551

GeneID:8651

Synonyms:JAB;JAK-binding protein;SOCS 1;SOCS1;SOCS-1;SSI-1;STAT-induced STAT inhibitor 1;Suppressor of cytokine signaling 1;Tec-interacting protein 3;TIP-3

Gene names:SOCS1

Standard solution:80ng/ml