Human Stress-activated protein kinase JNK3,MAPK10 ELISA KIT

SKU: E6701Hu

Size:96 Tests-1 Kit

Background:Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}.

Research_area:

Applications:ELISA

Target_protein:MAPK10

Reactivity:Human

Assay type:Sandwich

Sensitivity:13.19ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Stress-activated protein kinase JNK3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P53779

MASS(Da):52585

GeneID:5602

Synonyms:MAPK10 JNK3 JNK3A PRKM10 SAPK1B

Gene names:MAPK10

Standard solution:6400ng/L