Human Stem Cell Factor/Mast Cell Growth Factor, SCF/MGF ELISA Kit

SKU: E0135Hu

Size:96 Tests-1 Kit

Background:Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Research_area:Immunology

Applications:ELISA

Target_protein:KITLG

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.52pg/ml

Detection range:5-1800pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Stem Cell Factor/Mast Cell Growth Factor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P21583

MASS(Da):30,899

GeneID:4254

Synonyms:c-Kit ligand;Kit ligand;KITLG;Mast cell growth factor;MGF;SCF;sKITLG;Soluble KIT ligand;Stem cell factor;

Gene names:KITLG

Standard solution:2400pg/ml