Human Sialidase-4, NEU4 ELISA Kit

SKU: E3141Hu

Size:96 Tests-1 Kit

Background:Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed: 15847605, PubMed: 21521691, PubMed: 15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed: 21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed: 15847605).

Research_area:Neuroscience

Applications:ELISA

Target_protein:NEU4

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.17ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sialidase-4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8WWR8

MASS(Da):51,572

GeneID:129807

Synonyms:N-acetyl-alpha-neuraminidase 4;NEU 4;NEU4;Sialidase-4

Gene names:NEU4

Standard solution:6400ng/L