Human Sialic acid-binding Ig-like lectin 7,SIGLEC7 ELISA KIT

SKU: E7655Hu

Size:96 Tests-1 Kit

Background:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.

Research_area:

Applications:ELISA

Target_protein:SIGLEC7

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.27ng/ml

Detection range:0.63-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y286

MASS(Da):51143

GeneID:27036

Synonyms:SIGLEC7 AIRM1

Gene names:SIGLEC7

Standard solution:80ng/ml