Human Serine Threonine-protein Phosphatase PP1-alpha Catalytic Subunit, PPP1CA ELISA Kit

SKU: E6153Hu

Size:96 Tests-1 Kit

Background:Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). (Microbial infection) Necessary for alphaviruses replication.

Research_area:Signal Transduction; Cancer; Metabolism

Applications:ELISA

Target_protein:PPP1CA

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.95ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P62136

MASS(Da):37,512

GeneID:5499

Synonyms:PP1A;PP-1A;PP1alpha;PPP1A;PPP1CA;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Gene names:PPP1CA

Standard solution:3200ng/L