Human Serine, Threonine-protein Kinase Ulk2, ULK2 ELISA Kit

SKU: E6625Hu

Size:96 Tests-1 Kit

Background:Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:ULK2

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.14ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:serine/threonine-protein kinase ULK2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8IYT8

MASS(Da):112,694

GeneID:9706

Synonyms:ATG1B;Serine/threonine-protein kinase ULK2;ULK2;Unc51.2;Unc-51-like kinase 2

Gene names:ULK2

Standard solution:4000ng/L