Human Serine Threonine-protein Kinase Pak 3, PAK3 ELISA Kit

SKU: E6145Hu

Size:96 Tests-1 Kit

Background:Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:PAK3

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.35ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Serine/threonine-protein kinase PAK 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75914

MASS(Da):62,310

GeneID:5063

Synonyms:ARA;beta-PAK;bPAK;MRX30;MRX47;Oligophrenin-3;OPHN3;p21-activated kinase 3;PAK3;PAK-3;PAK3beta;Serine/threonine-protein kinase PAK 3

Gene names:PAK3

Standard solution:3200ng/L