Human Sentrin-specific Protease 1, SENP1 ELISA Kit

SKU: E6134Hu

Size:96 Tests-1 Kit

Background:Protease that catalyzes two essential functions in the SUMO pathway (PubMed: 10652325, PubMed: 15199155, PubMed: 16253240, PubMed: 16553580, PubMed: 21829689, PubMed: 21965678, PubMed: 23160374, PubMed: 24943844, PubMed: 25406032, PubMed: 29506078). The first is the hydrolysis of an alpha-linked Peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked Peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed: 16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed: 21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed: 23160374). Deconjugates SUMO2 from MTA1 (PubMed: 21965678). Deconjugates SUMO1 from METTL3 (PubMed: 29506078). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed: 25406032). Deconjugates SUMO1 from GPS2 (PubMed: 24943844).

Research_area:Cell Biology

Applications:ELISA

Target_protein:SENP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.88ng/L

Detection range:2-700ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sentrin-Specific Protease 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9P0U3

MASS(Da):73,481

GeneID:29843

Synonyms:SENP 1;SENP1;Sentrin/SUMO-specific protease SENP1;Sentrin-specific protease 1

Gene names:SENP1

Standard solution:800ng/L